The clinical findings in the Vogt -Koyanagi -Harad a syndrome are reviewed and eight cases
reported emphasizing the cutaneous changes.
The syndrome consists of symptoms of poliosis, vitiligo, alopecia, mcningeal irritation sign, nontraumatic uveitis, and dysacousia.
Meningeal or ocular symptoms usually appear first, but in some patients the cutaneous changes have been observed before the uveitis.
The etiology remains unsettled, but an allergic mechanism or a virus infection is favored by most observers. Early diagnosis is important because ocular morbidity can be reduced significantly in some patients if treated in the early stages.
During the course of treatment of our patients, corticosteroid is appeared to be the most effective drug for this uncertain etioiogic syndrome and this fact may eventually support the theory of autoimmue mechanism.
The daily does of corticosteroid is prednisolone 60 mg and the duration of administration is from 15 days to 2 months, after that the dose is gradually decreased in relation with the degree of symptoms.
The ophthalmologic symptoms were markedly improved 10 days after the administration of prednisolone.
The purpose of this report is to emphasize the cutaneous findings in this syndrome, to point out that the cutaneous manifestations may lead to establishing the diagnosis and on the basis of that, those patients can be received prompt, suitable treatment to avoid the grave ocular morbidity.
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